Precatoria Oil Extract Exporter (Research Only)

Product Definition: Precatoria Oil Extract (Abrin Source)

Our Precatoria Oil Extract is a raw, filtered extract derived from the seeds (beans) of the Abrus precatorius plant, commonly known as the Rosary Pea or Jequirity Bean. The extraction process (typically solvent-based or supercritical CO2 to maintain stability) is designed to capture a broad spectrum of the seed's compounds, including the toxic lectin **Abrin**.

This product is **not** purified Abrin. It is a crude or semi-refined **source material** from which research laboratories can isolate, purify, and characterize Abrin and other associated compounds (e.g., abrus-lectins, agglutinins). Its primary value is as a reliable, consistent, and legally-sourced starting material for complex research, eliminating the need for labs to source and handle the raw, highly dangerous seeds themselves.

The traditional use of Abrus precatorius in Ayurvedic and Siddha medicine involves a complex purification process (`Shodhana`) designed to *denature* (destroy) the toxic proteins. Our extract, by contrast, is processed to *preserve* these proteins for research. Therefore, any historical or traditional use data is **completely irrelevant and inapplicable** to this hazardous research-grade product.

Legitimate Research Applications (In-Depth)

Sale of this extract is restricted to the following verifiable research fields. All buyers must provide documentation attesting to one of these applications.

1. Toxicology & Pharmacokinetics

The primary use of this extract is in fundamental toxicology. Researchers utilize this material to:

• Study the mechanism of action of Abrin at a cellular level (e.g., ribosome inactivation, A-chain/B-chain interaction, apoptotic pathways).
• Investigate the *in vitro* and *in vivo* (animal model) toxicokinetics and toxicodynamics (ADME) of the toxin.
• Characterize the different isoforms of Abrin (Abrin-I, II, III, IV) and their varying levels of cytotoxicity.

2. Biosecurity, Forensic & Antitoxin Development

As a scheduled toxin, Abrin is a substance of high interest to global biosecurity and defense agencies.

• Antitoxin & Vaccine Research: The extract serves as the raw material to produce purified Abrin, which is then inactivated (toxoid) to immunize animals (e.g., rabbits, goats) for the development of polyclonal and monoclonal antibodies. These antibodies are the foundation for creating therapeutic antitoxins for Abrin exposure.
• Forensic Standard Development: National standards bureaus and forensic laboratories require a reliable source of Abrin to develop analytical reference materials. These standards are used to validate detection methods (e.g., ELISA, LC-MS/MS) for biosecurity and counter-terrorism screening.

3. Investigational Drug Development (Immunotoxins)

A highly specialized field of pharmaceutical R&D involves creating "immunotoxins." This is an advanced, experimental concept and is **not a current therapy**.

• Researchers isolate the toxic A-chain of Abrin (which stops protein synthesis).
• This A-chain is then chemically linked (conjugated) to a monoclonal antibody (mAb) that *only* targets a protein found on the surface of a cancer cell.
• The resulting "immunotoxin" is designed to, in theory, circulate harmlessly until it finds a cancer cell, bind to it, and then inject its toxic payload, killing the cancer cell specifically. This extract is a source material for the researchers undertaking the first steps of this complex research.

Technical Specifications (Representative)

This is a highly specialized product. All specifications are batch-dependent and will be fully documented on the Certificate of Analysis (COA) and Safety Data Sheet (SDS).

Strict Procurement & Vetting Protocol

AgroX Organic Exports adheres to all national and international guidelines for the transfer of hazardous materials. We **will not** sell this product to individuals, distributors, or any entity that cannot pass our rigorous vetting protocol.

1. Initial Inquiry: The inquiring party must be from an accredited university, government research agency (e.g., CDC, NIH, DRDO), or a known pharmaceutical/biotech company with a public R&D record.
2. Documentation Submission: The buyer must submit a formal purchase order on official letterhead, accompanied by a signed **End-Use and Non-Transfer Certificate**. This document must:
   • Clearly state the name and contact of the Principal Investigator (PI).
   • Describe the specific research application (e.g., "For *in vitro* study of Abrin's ribosomal inactivation pathway").
   • Attest that the material will *only* be used for the stated purpose, in a proper facility, by trained staff.
   • Attest that the material will *not* be resold or transferred to any third party.
3. Verification: Our compliance team will independently verify the identity of the institution and the PI.
4. Compliance & Legal Review: We check the buyer and destination against all national and international (e.g., UN, OPCW) controlled substance and denied-party lists.
5. Order Approval: Only after all steps are cleared is the order approved for processing and hazardous goods shipment.

Packaging & Global Logistics (Hazardous Goods)

This product is not shipped via standard courier. It is shipped as **Hazardous Goods / Dangerous Goods** in full compliance with IATA (air) and ADR (road) regulations.

• Packaging: The product is packed in a UN-specification, triple-layer-compliant system (leak-proof primary, leak-proof secondary, rigid outer packaging).
• Labeling: The outer package is clearly labeled with all required hazard pictograms (e.g., Skull and Crossbones) and the proper shipping name/UN number.
• Documentation: Shipments are accompanied by a Shipper's Declaration for Dangerous Goods, in addition to the standard COA, MSDS, and commercial invoice.
• Transport: We use only specialized freight forwarders who are certified to handle and transport highly toxic materials. The receiving institution must also be prepared to accept and sign for a hazardous goods shipment.

Visible FAQ — For Qualified Researchers

Compliance and Safety Documentation

Our commitment is to safety and responsible supply. All sales are governed by:

• Processing in a controlled, access-restricted facility with appropriate engineering controls.
• A comprehensive **Material Safety Data Sheet (SDS)** provided with every shipment.
• A **Certificate of Analysis (COA)** confirming botanical identity and key markers.
• Strict adherence to all Indian export laws and international regulations (e.g., Chemical Weapons Convention) for toxic materials.
• A full audit trail and chain-of-custody documentation.